1. This includes the strong desire to take the drug difficulties in controlling its use, persistence in its use despite harmful consequences, and sometimes a physical withdrawal state
2. This is the "feel-good" chemical in the human brain.
3. This is the harmful or hazardous use of psychoactive substance like alcohol and illicit drugs.
4. This is the use of drug for which it was not intended.
5. This is taken or administered for altering or controlling the physical, mental, or emotional state of the person.​