Answer:
Ginkgo biloba leaf extract was nominated to the NTP for a 2-year carcinogenicity bioassay[18] for the following reasons: (1) Ginkgo biloba leaf extract and its active ingredients have biological activities, (2) ginkgo extracts can be consumed in large doses over an extended period of time, and (3) some of ginkgo’s ingredients possess mutagenic activities. The NTP 2-year bioassay indicated that administration of Ginkgo biloba leaf extract caused carcinogenic activity in livers of mice
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