The distance between two points (x_1, y_1) and (x_2, y_2) can be defined as d= \sqrt{(x_2-x_1)^2 + (y_2-y_1)^2}. The Pythagorean Theorem is a mathematical relationship between the sides of a right triangle, given by a^2 + b^2 = c^2, where a and b are legs of the triangle and c is the hypotenuse of the triangle.